Bert van Marwijk’s men taught Milovan Rajevac’s Black Stars a lesson in a 4-1 demolition in Rotterdam.
Liverpool striker Dirk Kuyt opened the scoring for the hosts from close range after Ghana keeper Richard Kingson had saved a Robin van Persie shot.
Real Madrid star Rafael van der Vaart made it 2-0 to the Dutch in the 73rd minute after combining well with Mark van Bommel.
Asamoah Gyan reduced the deficit six minutes later but Wesley Sneijder hit back immediately for the hosts with an outrageous long-range effort from a corner.
Arsenal striker Van Persie completed the rout by converting a late penalty after Van der Vaart had been brought down by Kingson.